In most administrative forms, you will see a field for "middle name". That's where you'd put your second and third given names, separated by spaces.
For non-governmental business, eg bank, phone company, etc., usage of anything but your first given name is not usually required. I'd recommend not using your middle names as it can cause confusion: for example people might mistake one of your middle names for part of your last name, especially if they're used to the Hispanic practice of using two last names (paternal and maternal).
For immigration, federal tax and other federal business, you should use all your names to make sure you don't run into trouble verifying your identity with your passport. Depending on the state you live in, you may also have to use all your names on a driver's license (it's the case in California with their "true full name" requirement).
On freeform documents (when you're not filling out a form), Americans do not usually place commas between given names, eg "Charles François Marie DUPONT". Then again it would be rare to use all your names except on an administrative form. There can be a comma if you're writing last name first, eg "DUPONT, Charles François Marie". Regardless of first names, you may want to capitalize your last name in all-caps to clarify where the last name begins.